Table 1.
Demographic characteristics
| Baseline |
18 months |
36 months |
P-values | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HC | MCI | AD | HC | MCI | AD | HC | MCI | AD | ||
| N | 554 | 65 | 92 | 543 | 51 | 116 | 526 | 50 | 129 | |
| Age (mean SD) | 69.79 (6.51) | 74.84 (7.54) | 77.01 (7.43) | 71.12 (6.34) | 76.05 (7.28) | 78.68 (7.63) | 72.65 (6.26) | 77.56 (7.47) | 80.41 (7.39) | <.0001 |
| Gender (F/M) | 330/224 | 36/29 | 52/40 | 328/215 | 23/28 | 67/49 | 318/208 | 25/25 | 73/56 | >.05 |
| APOE ε4 (−ve/+ve) | 401/153 | 32/33 | 28/64 | 395/148 | 32/19 | 34/82 | 387/139 | 29/21 | 41/88 | <.0001 |
| MMSE (median IQR) | 29 (2) | 27 (3) | 21 (4.25) | 29 (2) | 27 (3) | 19 (8) | 29 (2) | 26.5 (3) | 16 (10) | <.0001 |
| SUVR (N) | 127 | 32 | 21 | 116 | 19 | 23 | 95 | 18 | 24 | |
| SUVR (mean SD) | 1.36 (0.38) | 2.02 (0.57) | 2.29 (0.5) | 1.35 (0.37) | 2.03 (0.63) | 2.32 (1.35) | 1.38 (0.37) | 1.8 (0.65) | 2.43 (0.53) | <.0001 |
Abbreviations: HC, healthy control; MCI, mild cognitive impairment; AD, Alzheimer's disease; SD, standard deviation; MMSE, Mini–Mental State Examination; IQR, interquartile range; SUVR, standardized uptake value ratio.