Table 4.
Cross-sectional differences between transitional, nontransitional, and stable AD group
| Biomarker | Time point | Mean (SD) |
All groups |
Nontransitional versus stable AD |
Nontransition versus transition |
Stable AD versus transition |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nontransition | Stable AD | Transition | Unadjusted | Adjusted | Unadjusted | Adjusted | Unadjusted | Adjusted | Unadjusted | Adjusted | ||
| TPO | 18 months | 734,927.17 (915,001.31) | 1,213,129.15 (1,769,353.4) | 892,786.19 (910,036.55) | 0.001 | 0.008 | 0.003 | 0.031 | 0.001 | 0.011 | 0.608 | 0.649 |
| IL-18 | 18 months | 785,441.3 (882,205.56) | 941,067.44 (1,499,137.36) | 864,354.28 (1,182,220.84) | 0.851 | 0.780 | 0.848 | 0.703 | 0.843 | 0.596 | 0.955 | 0.647 |
| FABP3 | 18 months | 656,531.23 (650,406.72) | 1,216,359.82 (1,600,944.1) | 1,210,246.46 (1,189,060.66) | 2.54E−09 | 0.089 | 4.66E−06 | 0.609 | 5.04E−10 | 0.108 | 0.732 | 0.407 |
| PPY | 18 months | 754,884.28 (942,461.94) | 1,100,224.7 (863,039.37) | 933,822.1 (1,500,440.09) | 0.001 | 0.645 | 1.59E−06 | 0.012 | 1.89E−04 | 0.244 | 0.005 | 0.005 |
| I309 | 18 months | 745,631.85 (889,056.6) | 1,177,579.61 (1,258,715.97) | 742,981.38 (861,920.76) | 0.037 | 0.307 | 1.16E−04 | 0.132 | 0.011 | 0.785 | 0.006 | 0.026 |
| SAA | 18 months | 725,269.34 (856,747.47) | 1,220,882.21 (1,766,987.01) | 892,634.17 (1,079,246.36) | 0.024 | 0.132 | 0.005 | 0.012 | 0.012 | 0.038 | 0.230 | 0.531 |
| CRP | 18 months | 802,298.22 (1,013,351.45) | 756,708.33 (1,093,736.16) | 931,625.38 (1,460,346.78) | 0.259 | 0.715 | 0.078 | 0.383 | 0.196 | 0.491 | 0.302 | 0.433 |
| sVCAM | 18 months | 692,349.99 (783,842.15) | 1,089,117.41 (1,411,766.29) | 970,385 (1,438,177.48) | 1.39E−04 | 0.695 | 0.001 | 0.580 | 5.73E−05 | 0.528 | 0.552 | 0.973 |
| sICAM | 18 months | 715,202.24 (925,269.56) | 954,110.77 (1,174,231.67) | 955,533.97 (1,243,870.25) | 0.013 | 0.720 | 0.040 | 0.758 | 0.011 | 0.732 | 0.880 | 0.732 |
| A2M | 18 months | 1,799,650,345.22 (534,498,021.57) | 1,976,590,545.15 (633,002,758.16) | 1,847,123,591.56 (500,192,450.05) | 0.006 | 0.611 | 0.006 | 0.669 | 0.310 | 0.798 | 0.196 | 0.312 |
| B2M | 18 months | 2,381,850.43 (907,635.57) | 2,765,830.14 (965,757.82) | 2,658,577.56 (1,076,595.34) | 5.79E−06 | 0.598 | 1.83E−05 | 0.267 | 0.012 | 0.989 | 0.246 | 0.500 |
| fVII | 18 months | 860,000.98 (217,912.04) | 896,958.07 (219,752.27) | 871,258.44 (219,811.81) | 0.150 | 0.197 | 0.127 | 0.553 | 0.639 | 0.431 | 0.452 | 0.932 |
| Adipo | 18 months | 73,569,851.3 (39,896,168.21) | 88,122,933.79 (49,723,473.27) | 91,055,858.46 (47,752,718.81) | 1.36E−05 | 0.046 | 0.002 | 0.148 | 1.61E−04 | 0.002 | 0.505 | 0.124 |
| ApoJ | 18 months | 35,079,670.75 (6,775,600.88) | 40,217,838.62 (8,576,304.99) | 37,220,101.86 (7,678,193.84) | 4.58E−09 | 2.54E−04 | 1.11E−09 | 2.20E−04 | 0.012 | 0.072 | 0.020 | 0.151 |
| TPO | 36 months | 703,881.17 (822,936.35) | 1,077,448.34 (1,296,890.2) | 788,618.72 (667,868.9) | 0.009 | 0.264 | 0.015 | 0.646 | 0.005 | 0.499 | 0.583 | 0.728 |
| IL-18 | 36 months | 746,645.04 (858,530.23) | 810,618.65 (1,376,366.07) | 838,000.74 (1,111,612.79) | 0.792 | 0.951 | 0.453 | 0.691 | 0.714 | 0.638 | 0.526 | 0.807 |
| FABP3 | 36 months | 822,703.27 (1,049,183.88) | 981,094.25 (933,201.02) | 1,201,488.19 (1,363,089.1) | 5.49E−05 | 0.855 | 0.006 | 0.292 | 5.38E−05 | 0.495 | 0.695 | 0.338 |
| PPY | 36 months | 781,974.64 (989,104.79) | 1,151,973.57 (1,092,561.08) | 954,990.77 (1,174,520.34) | 0.006 | 0.603 | 1.10E−04 | 0.059 | 0.002 | 0.445 | 0.046 | 0.054 |
| I309 | 36 months | 838,533.81 (1,078,746.36) | 1,353,072.01 (1,746,175.95) | 804,245.28 (931,700.18) | 0.145 | 0.071 | 1.10E−04 | 0.235 | 0.047 | 0.255 | 0.001 | 0.011 |
| SAA | 36 months | 767,652.82 (800,384.12) | 1,345,618.34 (1,628,667.49) | 981,199.98 (1,443,722.11) | 0.007 | 0.032 | 1.80E−04 | 0.004 | 0.002 | 0.007 | 0.063 | 0.327 |
| CRP | 36 months | 814,023.99 (954,192.13) | 1,026,815.36 (1,628,202.09) | 743,721.04 (864,164.17) | 0.326 | 0.893 | 0.979 | 0.328 | 0.382 | 0.887 | 0.416 | 0.354 |
| sVCAM | 36 months | 792,271.17 (881,653.84) | 1,384,448.99 (1,597,444.07) | 1,030,504.74 (1,333,138.23) | 5.53E−06 | 0.118 | 5.85E−07 | 0.005 | 4.81E−07 | 0.020 | 0.051 | 0.107 |
| sICAM | 36 months | 810,655.53 (993,834.31) | 1,252,178.56 (1,731,630.77) | 1,025,007.5 (1,135,948.28) | 0.004 | 0.431 | 0.003 | 0.269 | 0.002 | 0.206 | 0.353 | 0.473 |
| A2M | 36 months | 1,829,309,760.37 (546,555,071.17) | 1,994,538,938.13 (671,081,010.33) | 1,846,566,354.11 (471,139,174.28) | 0.133 | 0.671 | 0.030 | 0.503 | 0.929 | 0.366 | 0.059 | 0.236 |
| B2M | 36 months | 2,449,468.3 (902,701.5) | 2,906,874.61 (1,081,026.87) | 2,732,263.3 (1,245,439.21) | 9.75E−05 | 0.181 | 1.34E−04 | 0.125 | 0.038 | 0.580 | 0.133 | 0.315 |
| fVII | 36 months | 858,762.71 (211,954.37) | 908,875.33 (231,706.93) | 888,053.93 (244,355.77) | 0.524 | 0.574 | 0.242 | 0.613 | 0.760 | 0.678 | 0.238 | 0.182 |
| Adipo | 36 months | 76,456,574.56 (42,427,744.89) | 89,827,129.94 (50,476,152.8) | 96,095,398.58 (98,293,155.58) | 0.001 | 0.096 | 1.76E−04 | 0.025 | 0.212 | 0.443 | 0.023 | 0.286 |
| ApoJ | 36 months | 35,837,220.52 (6,875,230.87) | 40,429,122.93 (8,704,482.98) | 37,761,901.99 (7,900,428.96) | 0.003 | 0.061 | 0.015 | 0.205 | 0.048 | 0.152 | 0.556 | 0.552 |
Abbreviations: AD, Alzheimer's disease; SD, standard deviation; TPO, thrombopoietin; IL-18, interleukin-18; FABP3, fatty acid binding protein; PPY, pancreatic polypeptide Y; I309, chemokine I309; SAA, serum amyloid A; CRP, C-reactive protein; sVCAM, soluble vascular adhesion molecule; sICAM, soluble intercellular adhesion molecule; A2M, alpha-2-macroglobulin; B2M, beta-2 microglobulin; FVII, Factor VII; adipo, adiponectin; apoJ, apolipoprotein J.