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. Author manuscript; available in PMC: 2018 Mar 14.
Published in final edited form as: Circulation. 2016 Dec 27;135(11):1011–1020. doi: 10.1161/CIRCULATIONAHA.116.024421

Figure 4. Effects of pharmacologic r-tPA and α2-antiplasmin inactivation on thrombus dissolution in mice with experimental pulmonary emboli.

Figure 4

Anesthetized mice were treated thirty minutes after thromboembolism with r-tPA, an α2-antiplasmin-inactivating antibody (a2AP-I) alone, the combination of low dose r-tPA and a2AP-I or nothing (Control) as shown (N=48). Four hours after PE, the experiments were terminated and thrombus dissolution was measured. The number of mice per dose is shown. *** p<0.001 vs. control; ^^^ p<0.001 vs. r-tPA 0.1, 0.24 or 1.2 mg/kg; # p<0.05 vs. r-tPA 3 mg/kg.