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. 2017 Apr-Jun;12(2):175–182. doi: 10.4103/jovr.jovr_243_16

Figure 6.

Figure 6

Sensitive detection of endothelial injury by mimicking leukocyte function. Under normal conditions, leukocytes freely flow in the bloodstream and do not interact with healthy endothelia (upper left). Diabetic endothelia express ICAM-1, which mediates firm leukocyte adhesion (upper right). Imaging probes that target endothelial ICAM-1 apply this principle to detect early vascular changes in vivo. α-ICAM-1 probes that target endothelial ICAM-1 show significantly higher interaction with diabetic endothelia (lower right) than in those of normal animals (lower left).