Table 1.

Direct Protein Targets Identified by LC-MS/MS

	KA-ARTD1^a	KA-ARTD2^a	IG-ARTD10	IG-ARTD11
Total Proteins Identified	123	488	961	479
Proteins with ≥ 2 Unique Peptides	91	428	848	294
Proteins Enriched Above Background^b	38	279	803	260
Proteins Identified in Duplicate	16	N.D.^d	140	21
ARTD Family-Member Specific Proteins^c	13/14	117/N.D.^d	537/94	43/13

KA-ARTD1 and KA-ARTD2 targets were identified as previously described (Carter-O’Connell et al., 2014)

Defined as ≥ 2-fold enrichment in the IG-ARTD sample versus the WT-ARTD sample

Targets that were identified for a single ARTD family-member from the collected datasets from either at least a single replicate (left) or in duplicate (right)

KA-ARTD2 identification was completed for a single replicate and is not included in the duplicate analysis