Table 1.
List of functional molecules used with Ad-based vectors in clinical trials in the USA.
| Function | Gene | Cancer type | Clinical trial Code |
|---|---|---|---|
| Cytokine | IFNβ | Pleural Mesothelioma, Colorectal Carcinoma | NCT00299962, NCT00107861 |
| IFNα2b | Mesothelioma | NCT01212367 | |
| IFNγ | B-Cell Lymphoma | NCT00394693 | |
| IL-12 | Breast Cancer, Colorectal Cancer, Prostate Cancer, Melanoma, Neoplasms | NCT00849459, NCT00072098, NCT00406939, NCT01397708, NCT00110526 | |
| IL-2 | Neuroblastoma | NCT00048386 | |
| MDA-7 (IL-24) | Malignant Melanoma | NCT00116363 | |
| TNFα | Esophageal Cancer, Pancreatic Cancer | NCT00051480, NCT00051467 | |
| GM-CSF | Malignant Solid Tumor | NCT01598129 | |
| FLt3L | Malignant Glioma | NCT01811992 | |
| Tumor suppressor | p53 | Squamous Carcinoma, Lip and Oral Cavity Cancer, Head and Neck Carcinoma, Brain Tumors, Liver Cancer, Ovarian Cancer, Lung Cancer, Bladder Cancer, Breast Cancer | NCT00041613, NCT00064103, NCT00004041, NCT00003147, NCT00003880, NCT00003649, NCT00003167 |
| REIC/Dkk-3 | Prostate cancer | NCT01197209 | |
| RTVP-1 | Prostatic Neoplasms | NCT00403221 | |
| Suicide molecule | TK | Malignant Glioma, Brain Tumors, Hepatocellular Carcinoma, Ovarian Cancer, Melanoma, Pancreatic Cancer | NCT01811992, NCT00002824, NCT00844623, NCT00638612, NCT00005057 |
| Costimulatory molecule | CD40L | Malignant Melanoma, Bladder Cancer, Breast Cancer, Neoplasms, Leukemia, Lymphoma | NCT01455259, NCT00706615, NCT00504322, NCT00942409 |
| Anti-angiogenic molecule | Endostatin | Head and Neck Squamous Carcinoma, Advanced solid tumors | NCT00634595, NCT00262327 |
| Antigen | PSA | Prostate cancer | NCT00583752 |