Table 1.
Oncolytic viruses that have been studied in thoracic cancers.
| Oncolytic Virus | Disease | Immune Mechanism Studied | Phase of Development | Author/Year/Journal |
|---|---|---|---|---|
| Adenovirus | NSCLC | N/A | Pre-Clinical Data: Nude Mice | Zhang, J.-F., et al., 2010. [19]. |
| NSCLC | Neoantigen Specific Response; Checkpoint-Inhibitors; CD8+ Tumor Infiltration | Pre-Clinical Data: Immune Competent Mice, CD8+ Depleted Mice | Woller, N., et al., 2015. [20]. | |
| MPM | N/A | Pre-Clinical Data: Athymic Mice | Kubo, S., et al., 2010. [21]. | |
| Cocksackie B3 Virus | NSCLC | Immunogenic Cell Death | Pre-Clinical Data: Immune Competent Mice | Miyamoto, S. et al., 2012. [22]. |
| Herpes Simplex Virus | NSCLC | N/A | Pre-Clinical Data: Murine Lung Cancer Model | Goodwin et al., 2012. [23]. |
| NSCLC | N/A | Pre-Clinical Data: In Vitro Work | Li, J.-M., et al., 2013. [24]. | |
| MPM | N/A | Pre-Clinical Data: Athymic Mice | Adusumilli, P.S., et al. 2006 [25]. | |
| Measles Virus | MPM | DC Maturation; CD8+ Priming | Pre-Clinical Data: In Vitro Work | Gauvrit, A., et al., 2008. [26]. |
| MPM | Innate Immune Infiltration by Macrophages/Monocytes | Pre-Clinical Data: Athymic Mice | Li, H., et al., 2010. [17]. | |
| NSCLC | N/A | Pre-Clinical Data: Nude Mice | Patel, M.R., et al., 2014. [27]. | |
| Newcastle Disease Virus | NSCLC | N/A | Pre-Clinical Data: In Vitro Work | Meng, G., et al., 2014. [28]. |
| NSCLC | N/A | Pre-Clinical Data: In Vitro Work | Fu, F., et al., 2011. [29]. | |
| Reovirus | NSCLC | N/A | Phase I Clinical Trial w/Paclitaxel and Carboplatin | Villalona-Calero, M.A., et al., 2016. [13]. |
| NSCLC | N/A | Pre-Clinical Data: In Vitro Work | Sei, S., et al., 2009. [14]. | |
| NSCLC | Cytokine Induction | Pre-Clinical Data: Mice Models | Campion, C.A., et al., 2016. [30]. | |
| NSCLC | Increased Antigen Presentation | Pre-Clinical Mouse Model | Gujar, S.A., et al., 2010 [31]. | |
| Vaccinia Virus | NSCLC | Cytokine Expression and CD8+ Tumor Infiltration | Pre-Clinical Data: Immune Competent Mice | Wang, L.-C.S., et al., 2011. [15]. |
| MPM | N/A | Pre-Clinical Data: Immune Competent Mice | Acuna, S.A., et al., 2014. [32]. | |
| MPM | N/A | Pre-Clinical Data: Athymic Mice | Belin, L.J., et al., 2013. [33]. | |
| MPM | N/A | Pre-Clinical Data: Athymic Mice | Kelly, K.J., et al., 2008. [34]. | |
| Vesicular Stomatitis Virus | NSCLC | CD8+ Infiltration, TILs, PDL-1 Expression | Pre-Clinical Data: Immune Competent Mice | Patel et al., 2015. [8]. |
| MPM | Interferon Response | Pre-Clinical Data: SCID Mice | Saloura, V., et al., 2010. [9]. | |
| MPM | CD8+ T Cell and NK Cell Infiltration | Pre-Clinical Data: Immune Competent Mice | Willmon, C.L., et al., 2009. [16]. |
DC = Dendritic Cell, TIL= tumor infiltrating lymphocytes, NK = Natural Killer, SCID = Severe combined immunodeficient, N/A = Not applicable.