Figure 2.

The cytoadherence of infected erythrocytes to red blood cell and endothelial cell promotes the formation of rosetting, sequestration and platelet clumping. These infected erythrocytes (IEs) bind to a number of host receptors on the endothelial cell through tethering, rolling, and adhesion of IE on the surface. This cytoadherence of IEs to the host endothelial surface receptor prevents parasite clearance by the spleen. The diagram is modified from Rowe et al. (2009) [21].