Table 1.
TAA-encoding OVs used for anti-tumor vaccination.
| Virus | Antigen | Tumor Model | Strategy |
|---|---|---|---|
| Ad | CEA | MC38 | Boosting agent following DNA prime [91] |
| Ad | DCT | B16F10 | Heterologous virus prime-boost [78,90] |
| Ad | gp33 | B16F10 | Heterologous virus prime-boost [92] |
| Ad | MART-1 | NSFA-MART-1 | Transduced dendritic cells as a prime [93] |
| Ad | PSA/PSCA | RM11-PSA | Stand alone priming agent [94,95] |
| HSV | PAP | TRAMP-C2 | Stand alone treatment [96] |
| Maraba | DCT | B16F10 | Boosting agent following Ad prime [90] |
| NDV | LacZ | CT26-LacZ | Stand alone treatment [97] |
| Semliki Forest | Ova | MOSE-Ova | Heterologous virus prime-boost [98] |
| Sindbis | E7 | TC-1 | Encoding HSP70 and E7 as a priming agent [99] |
| Sindbis | LacZ | CT26-LacZ | Replication defective virus for vaccination [100] |
| Vaccinia | 5T4 | B16F10, CT26 | Stand alone treatment [80] |
| Vaccinia | CEA | MC38-CEA | Stand alone treatment [79], Heterologous virus prime-boost priming [101], Co administration with vaccinia-B7 [101], Encoding B7-1, ICAM-1 and LFA-3 [87,102] |
| Vaccinia | E6/E7 | MRC-5, TC-1 | Stand alone [103], Boosting agent following DNA priming [99], Encoding HSP70 and E7 as a boosting agent [99] |
| Vaccinia | EphA2 | A549 | Encoding Bi-specific T cell engager [104] |
| Vaccinia | gp33 | B16F10 | Heterologous virus prime-boost priming [92] |
| Vaccinia | HY | MB49 | Encoding GM-CSF [86] |
| Vaccinia | Ova | MOSE-Ova | Heterologous virus prime-boost [98] |
| VSV | BRAF | B16F10 | Stand alone treatment [105] |
| VSV | DCT | B16F10 | Boosting agent following Ad prime [78] |
| VSV | E6/E7 | TC-1 | Stand alone treatment [106] |
| VSV | gp-100 | B16F10-Ova | Stand alone treatment [107,108] |
| VSV | Ova | B16F10-Ova | Stand alone treatment [7,107,108,109], VSV-infected dendritic cells [78], VSV-infected B cells [92] |
| VSV | gp33 | B16-F10-Ova | VSV-infected B cells as boosting agent [92] |
| VSV | various | B16F10 | Clones isolated from a cDNA library. Antigens: HIF-2a, Sox-10, c-Myc, TYRP-1, N-Ras and Cyt-c [110,111,112] |
Ad: adenovirus; BRAF: serine/threonine-protein kinase B-raf; CEA: carcinoembryonic antigen; DCT: dopachrome tautomerase; GM-CSF: granylocyte macrophage colony-stimulating factor; HSV: herpes simplex virus; ICAM-1: intercellular adhesion molecule-1; MART: melanoma antigen recognized by T cells; PAP: prostatic acid phosphatase; PSA: prostate specific antigen; PSCA: prostate stem cell antigen; VSV: vesicular stomatitis virus.