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Consort diagram for three‐drug combinations. Articles identified from the PubMed search were screened to identify three‐drug combinations of cytotoxic and targeted agents that included at least one targeted agent. Studies including immunotherapy, radiation, organ dysfunction (renal and liver failure), pediatric patients, exclusively elderly patients, or those administering one drug of the combination at greater than the FDA‐approved/RP2D/MTD dose were excluded from the analysis.
