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. Author manuscript; available in PMC: 2017 May 9.
Published in final edited form as: For Immunopathol Dis Therap. 2016;7(1-2):127–139. doi: 10.1615/ForumImmunDisTher.2016017227

FIG. 2.

FIG. 2

Roles of KLF4 as oncogene in human glioblastoma. KLF4 is highly expressed to function as an oncogene in heterogenic glioblastoma cells, especially in GSCs, in this solid tumor. Hypoxia has an important role in promoting expression of KLF4 in GSCs and other glioblastoma cells. Radiotherapy and chemotherapy fail to kill every GSC in the tumor, and only a few GSCs remaining after therapeutic treatments can regrow the tumor that can, in turn, produce more GSCs to perpetuate malignant tumor growth.