Table 3.

Recommendations if multiple risk factors (Table 2) are present.

Systemic antimicrobial prophylaxis - in addition to mouth rinsing with 0.2% chlorhexidine - should be considered.

Cases with multiple risk factors are rare (including those in which the dental procedures cannot be delayed). We do not think it is meaningful to publish generalizable recommendations on antimicrobial substances for such a minority of patients.

Multidisciplinary case discussion (including the physician managing the patient's comorbidity or immunosuppressive drugs, infectious diseases specialist, orthopaedic surgeon).

Consideration of performing the dental procedure at a centre where a corresponding specialist is available.