Table 5.
Papers looking at outcome of long bone osteomyelitis in humans with ceramic antibiotic carriers.
| Paper | Material (Contents) | Number treated | Mean Age | Male: female | Mean follow up (yrs) | Infection recurrence | Fracture | Bone filling | Wound leak |
|---|---|---|---|---|---|---|---|---|---|
| McKee et al. 2002 (16) | Osteoset T (Calcium sulphate Tobramycin) |
25 | 44.1 | 15/10 | 2.3 (1.7-3.2) |
2/25 (8%) |
3/25 (12%) |
9 required bone graft | 8/25 (32%) |
| Gitelis et al. 2002 (17) | Osteoset T (Calcium sulphate Tobramycin |
6 | 50.0 (26-85) |
3/3 | 2.3 (1.5-3.3) |
0/6 (0%) |
0/6 (0%) |
91% bone ingrowth at final follow up | No significant drainage |
| Chang et al. 2007 (18) | Osteoset T (Calcium sulphate Tobramycin) |
25 | 39.8 (18-69) |
Unknown | Unknown | 5/25 (20%) |
Unknown | 40% bone ingrowth at 1 year | Unknown |
| McKee et al. 2010 (19) | Osteoset T (Calcium sulphate Tobramycin) |
14 | 44.1 | 11/4 | 3.2 (2.2-5) |
2/14 (14%) |
2/14 (14%) |
Not clear (Mean void consolidation time 6 months) |
3/14 (21%) |
| Fleiter et al. 2014 (9) | Herafill G (Calcium sulphate Calcium carbonate Gentamicin) |
20 | 51.1 (24-79) |
16/4 | Not stated (Only 1/20 patients had long term follow up) | 4/20 (20%) |
Unknown | Unknown | Unknown (used drains) |
| Ferguson et al. 2014 (21) | Osteoset T (Calcium sulphate Tobramycin) |
193 | 46.1 (16-82) |
150/43 | 3.7 (1.3-7.1) |
18/193 (9%) |
9/193 (4.7%) |
36.6% no filling 59.0% partial filling 4.4% complete filling |
30/193 (15.5%) |
| Humm et al. 2014 (20) | Osteoset T (Calcium sulphate Tobramycin) |
21 | 49 (26-88) |
18/3 | 1.3 (0.5-2.1) |
1/20 (5%) |
Unknown | Unknown | 7/21 (33.3%) |
| Romanò et al. 2014 (22) | PerOssal (Calcium sulphate Hydroxyapatite Antibiotic targeted to organism) |
27 | 47 (24-74) |
16/11 | 1.8 (1-3) |
3/27 (11.1%) |
0/27 (0%) |
Partial incorporation | 8/27 (29.6%) |
| Romanò et al. 2014 (22) | Calcium deficient hydroxyapatite (Bovine collagen Teicoplanin) |
22 | 45 (23-77) |
14/8 | 1.8 (1-3) |
3/22 (13.6%) |
0/22 (0%) |
Partial incorporation | 6/22 (27.3%) |
| McNally et al. 2016 (65) | Cerament G (Calcium sulphate Hydroxyapatite Gentamicin) |
100 | 51.6 (23-88) |
65/35 | 1.6 (1-2.8) |
4/100 (4%) |
3/100 (3%) |
Unknown | 6/100 (6%) |