Table 2.

Overview of the initial treatment and the antibiotic suppressive therapy (AST) per patient, the reported side effects and subsequent intervention.

Pt	Intravenous treatment1	Oral treatment2	1st AST	Side effects AST	Change of treatment	2nd AST	Side effects AST	Change of treatment
1	Penicillin 12 mU /day	Amoxicillin 1000 mg TID	Amoxicillin 500 mg TID	No	-	-	-	-
2	Vancomycin/day3, 4w	Minocycline 100 mg BID	Minocycline 100 mg BID	Nausea, phototoxicity	Yes	Minocycline 100 mg QD	Phototoxicity	No
3	Penicillin 12 mU/day	Moxifloxacin 400 mg QD Rifampin4 450 mg BID	Moxifloxacin 400 mg QD	No	-	-	-	-
4	Vancomycin/day3 Ciprofloxacin 400 mg TID	Ciprofloxacin 750 mg BID Rifampin4 450 mg BID Linezolid 600 mg BID, 4w Mincocyline 100 mg BID, 6w	Minocycline 100 mg BID	Nausea, vomiting	Yes	Doxycyclin 100 mg QD	No	-
5	-	-	Moxifloxacin 400 mg QD	Nausea	No	-	-	-
6	Amoxicillin 12 g/day Flucloxacillin 12 g/day Gentamicin 3 mg/kg/day	Amox/clav 500/125 QID Rifampin4 450 mg BID	Amox/clav 500/125 mg TID	No	-	-	-	-
7	- -	Metronidazole 500 mg QID Amox/clav 750/125 TID	Amox/clav 500/125 mg TID	Nausea	Yes	Minocycline 100 mg QD	Dizziness	No
8	Vancomycin/day3	Mincocyline 100 mg BID	Minocycline 100 mg QD	No	-	-	-	-
9	Ceftriaxone 2 g QD	Clindamycin 600 mg TID Rifampin4 450 mg BID	Amoxicillin 500 mg TID	Dry mouth	Yes	Amoxicillin 375 mg TID	Malaise	No
10	Flucloxacillin 12 g/day	Moxifloxacin 400 mg QD Rifampin4 450 mg BID	Clindamycin 450 mg TID	No	-	-	-	-
11	-	Linezolid 600 mg BID, 4w Mincocyline 100 mg BID, 8w	Minocycline 100 mg BID	Diarrhea	Yes	Minocycline 100 mg QD	No	-
12	Flucloxacillin 12 g/day	Moxifloxacin 400 mg QD Rifampin4 450 mg BID	Clindamycin 450 mg TID	Nausea	Yes	Moxifloxacin 400 mg QD	No	-
13	Flucloxacillin 12 g/day	Moxifloxacin 400 mg QD Rifampin4 450 mg BID	Clindamycin 600 mg TID	No	-	-	-	-
14	Vancomycin/day3	Linezolid 600 mg BID, 4w Mincocyline 100 mg BID, 6w	Minocycline 100 mg QD	No	-	-	-	-
15	-	Clindamycin 600 mg TID	Clindamycin 600 mg TID	Loss of appetite	Yes	Clindamycin 300 mg TID	No	-
16	Flucloxacillin 8 g5/day, 1w	Clindamycin 600 mg TID	Clindamycin 600 mg TID	No	-	-	-	-
17	Daptomycin 8 mg/kg/day6	Mincocyline 100 mg BID Rifampin4 450 mg BID	Minocycline 100 mg BID	Skin rash	Yes	Cotrimoxazole 960 mg BID	No	-
18	Flucloxacillin 8 g/day5	Moxifloxacin 400 mg QD Rifampin4 450 mg BID	Clindamycin 600 mg TID	No	-	-	-	-
19	Meropenem 2 g TID Vancomycin/day3 Gentamicin 3 mg/kg/day	Ciprofloxacin 750 mg BID Amoxicillin 1000 mg TID	Cotrimoxazole 960 mg BID Amoxicillin 1000 mg TID	No No	- -	- -	- -	- -
20	Penicillin 12 mU/day, 4w Gentamicin 3 mg/kg/day, 4w	Amoxicillin 1000 mg TID, 8w	Amoxicillin 500 mg TID	No	-	-	-	-
21	-	-	Clindamycin 450 mg TID	No	-	-	-	-

¹ Intravenous treatment comprises 2 weeks of treatment, unless otherwise stated. ² Oral treatment comprises 10 weeks of treatment, unless otherwise stated. ³ The dose of vancomycin was determined by therapeutic drug monitoring, aiming towards a serum concentration level of ±25 mg/L (continuous infusion). ⁴ In general, rifampin is added during intravenous treatment after susceptibility is known (after ± 5 days). ⁵ 8 grams of flucloxacillin was chosen because of renal insufficiency. ⁶ Daptomycin was chosen because of allergy to penicillin.