Table 1.
Comparison of orthopedic infections due to Gram-negative versus other pathogens at Geneva University Hospitals, 2004-2014.
| Other pathogens | Gram-negative pathogens | ||
|---|---|---|---|
| n=1410 (77%) | p value | n=430 (23%) | |
| Patient characteristics | |||
| F:M (percentage of female) | 491:919 (35%) | ns | 161:269 (37%) |
| Median age | 54 years | <0.01 | 61 years |
| - Age < 51 years | 615 (44%) | <0.01 | 150 (35%) |
| - Age 51 to 80 years | 638 (45%) | <0.01 | 226 (53%) |
| - Age > 80 years | 157 (11%) | ns | 54 (13%) |
| Median serum C-reactive protein level | 81 mg/L | ns | 88 mg/L |
| - CRP < 51mg/L | 427 (30%) | <0.05 | 108 (25%) |
| - CRP 51 to 200mg/L | 432 (31%) | 139 (32%) | |
| - CRP > 200mg/L | 551 (39%) | 183 (43%) | |
| Prior antibiotic use | 561 (40%) | <0.01 | 229 (53%) |
| Median duration of prior antibiotic use | 4 days | ns | 5 days |
| Immune compromised+ | 439 (31%) | 0.02 | 159 (37%) |
| - Diabetes mellitus | 230 (16%) | <0.01 | 101 (24%) |
| Type of infection | |||
| Osteoarticular infections | 808 (57%) | <0.01 | 215 (50%) |
| All implant-associated infections | 488 (35%) | ns | 146 (34%) |
| - Prosthetic joint infections | 251 (18%) | ns | 70 (16%) |
| - Spondylodesis infections | 20 (1%) | <0.05 | 11 (2%) |
| - Nail infections | 40 (3%) | ns | 13 (3%) |
| - Plate infections | 107 (8%) | ns | 28 (7%) |
| Soft tissue abscess | 396 (28%) | ns | 102 (24%) |
| Shoulder infections | 82 (6%) | <0.01 | 10 (2%) |
| Spine infections | 20 (1%) | ns | 11 (3%) |
| Polymicrobial infections | 188 (15%) | <0.01 | 207 (48%) |
ns = not significant
+ = diabetes, immune-suppressive medication, dialysis, active cancer, untreated HIV disease, cirrhosis CHILD C, pregnancy, splenectomy.