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. 2017 May 9;12(5):e0176988. doi: 10.1371/journal.pone.0176988

Fig 9. Efficacy of the 2.6 kDa chitosan used alone or in combination with tilmicosin on S. aureus in a mouse mastitis model.

Fig 9

(A) Chitosan was administered twice at (0 h and 4 h post-inoculation) using 0.2, 2 or 10 mg/gland for the challenge against S. aureus strain Newbould. (B) A challenge with S. aureus strain 2117 was treated with the 2.6 kDa chitosan or tilmicosin (TIL) or a combination of both. Chitosan was administered twice at (0h and 4 h post-inoculation) whereas tilmicosin was administered 4 h post-inoculation. The middle bars indicate median values for each group of glands (n = 5–8) whereas the boxes specify quartiles Q1-Q3. The detection limit was 200 CFU (dotted line), below that, the glands were considered uninfected. Statistical analysis was performed using the Kruskal-Wallis test: *, P<0.05; ***, P<0.001.