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. 2017 May 9;12(5):e0177279. doi: 10.1371/journal.pone.0177279

Fig 1. Purified A1AT reduces SERPINA1 expression in a dose-dependent manner in primary human hepatocytes.

Fig 1

(A) Exogenously added purified A1AT reduced SERPINA1 expression in primary human hepatocytes isolated from both proficient and deficient liver tissue. The reduction was more prominent following Oncostatin M (10ng/ml) stimulation (Kruskal-Wallis test on ranks). SERPINA1 gene expression was reduced in a dose-dependent manner with marked decrease at A1AT levels of >1 mg/ml (B) Oncostatin M showed increased expression of SERPINA1 in primary human hepatocytes (Mann-Whitney U test), * P<0.05, ** P <.001, *** P<0.001, **** P<0.0001).