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SERPINA1 gene expression in lung tissue from PiZZ patients receiving purified A1AT (Prolastin) therapy (n = 10) compared to PiZZ patients without therapy (n = 4) showed similar tendencies to other cell types investigated. There might be reduced SERPINA1 expression in treated PiZZ patients, the difference did however not reach statistical significance (P = 0.0539, Mann-Whitney U test).
