Table 1.

Blood and urinary chemistry in wild-type (WT) and all-UT-knockout (KO) mice

	WT	KO	KO/WT
Body weight, g	26.0±0.4	25.6±0.5	0.98
Urine
Urine output, ml/day	1.8±0.2	6.4±0.4*	3.55
Urine osmolality, mosm/kg H2O	2503±85	941±53*	0.37
Urine urea concentration, mmol/L	2253±57	797±39*	0.35
Urine creatinine concentration, mmol/L	16.4±0.9	5.2±0.4*	0.31
Osmolar excretion, osm/day	5.6±0.4	5.3±0.3	0.95
Urea excretion, mmol/day	3.9±0.6	4.3±0.2	1.1
Plasma and clearances
Plasma urea concentration, mmol/L	9.2±0.3	9.9±0.7	1.07
Plasma creatinine concentration, μmol/L	35±0.9	37±0.8	1.06
Plasma potassium concentration, mmol/L	6.9±0.2	6.9±0.2	1
Plasma sodium concentration, mmol/L	156±0.8	156±1.3	1
Plasma chloride concentration, mmol/L	110±0.4	111±1	1.01
Plasma calcium concentration, mmol/L	2.5±0.1	2.6±0.1	1.04
Urea clearance, ml/day	441±26	512±41	1.16
Creatinine clearance, ml/day	842±39	896±47	1.06
Urea clearance/creatinine clearance	0.52±0.01	0.57±0.01	1.09
Urine-to-plasma ratios
U/Purea	245±37	80±21*	0.32
U/Pcreatinine	468±32	140±17*	0.30
Plasma lipid
Plasma TG concentration, mmol/L	1.23±0.08	1.31±0.16	1.06
Plasma HDL concentration, mmol/L	1.13±0.04	1.30±0.10	1.15
Plasma HDL concentration, mmol/L	0.21±0.01	0.18±0.01	0.85

Values are means±SE of 6 mice/group.

^*P<0.05 compared with WT mice.