ATP-competitive inhibitors |
Bisindolylmaleimide I |
Non-selective |
Other kinases |
Yes |
Gö6976 |
cPKCs |
Enzastaurin |
Some selectivity for PKCβ |
C1 domain ligands |
Bryostatin 1 |
cPKC/nPKC activator in vitro, functional inhibitor in cells/in vivo
|
“Non-PKC” phorbol ester receptors (PKDs, RasGRPs, chimaerins, others) |
Yes |
Protein-protein interaction inhibitors |
Aurothiomalate |
PKCι (inhibits interaction with Par6) |
Unknown |
Yes |
εV1-2 |
PKCε (inhibits interaction with RACK) |
Yes |
Substrate-competitive inhibitors |
Pseudosubstrate-derived peptides |
Limited |
Unknown |
No |
PIF-pocket inhibitors |
PS315 |
Unknown |
Unknown |
Unknown |