. Author manuscript; available in PMC: 2018 Jun 1.

Published in final edited form as: Mol Carcinog. 2017 Mar 10;56(6):1531–1542. doi: 10.1002/mc.22617

Table 1.

Most common classes of PKC inhibitors

Class	Examples	PKC isozyme selectivity	Other targets	Potential as anticancer agents
ATP-competitive inhibitors	Bisindolylmaleimide I	Non-selective	Other kinases	Yes
	Gö6976	cPKCs
	Enzastaurin	Some selectivity for PKCβ
C1 domain ligands	Bryostatin 1	cPKC/nPKC activator in vitro, functional inhibitor in cells/in vivo	“Non-PKC” phorbol ester receptors (PKDs, RasGRPs, chimaerins, others)	Yes
Protein-protein interaction inhibitors	Aurothiomalate	PKCι (inhibits interaction with Par6)	Unknown	Yes
Protein-protein interaction inhibitors	εV1-2	PKCε (inhibits interaction with RACK)	Unknown	Yes
Substrate-competitive inhibitors	Pseudosubstrate-derived peptides	Limited	Unknown	No
PIF-pocket inhibitors	PS315	Unknown	Unknown	Unknown