Table 2.

Risk of Hospitalization, Stroke, and Death with Atrial Fibrillation (N=3,385)

Outcome	Events	Incidence rate per 100 person-years	Model 1* HR (95%CI)	P-value	Model 2† HR (95%CI)	P-value	Interaction P-value
Hospitalization
All	1,524	18.9 (18.1, 19.9)	1.52 (1.37, 1.69)	<0.001	1.49 (1.34, 1.66)	<0.001
Women	733	17.1 (15.9, 18.4)	1.70 (1.46, 1.98)	<0.001	1.63 (1.40, 1.91)	<0.001	0.032
Men	791	21.2 (19.7, 22.7)	1.38 (1.19, 1.58)	<0.001	1.37 (1.18, 1.58)	<0.001
Hospitalization for Heart Failure
All	437	4.1 (3.7, 4.5)	1.55 (1.28, 1.88)	<0.001	1.49 (1.23, 1.81)	<0.001
Women	207	3.7 (3.2, 4.3)	1.66 (1.25, 2.20)	<0.001	1.54 (1.15, 2.06)	0.0040	0.94
Men	230	4.5 (4.0, 5.2)	1.47 (1.13, 1.92)	0.0039	1.47 (1.12, 1.92)	0.0048
Stroke
All	115	1.0 (0.85, 1.23)	1.94 (1.33, 2.83)	<0.001	2.10 (1.43, 3.09)	<0.001
Women	61	1.0 (0.8, 1.3)	2.31 (1.37, 3.90)	0.0018	2.58 (1.49, 4.48)	<0.001	0.54
Men	54	1.0 (0.8, 1.3)	1.65 (0.96, 2.84)	0.071	1.77 (1.02, 3.08)	0.042
Death
All	516	4.5 (4.2, 4.9)	1.27 (1.07, 1.52)	0.0080	1.22 (1.02, 1.47)	0.031
Women	213	3.6 (3.1, 4.1)	1.33 (1.00, 1.76)	0.047	1.31 (0.98, 1.75)	0.069	0.68
Men	303	5.6 (4.9, 6.2)	1.23 (0.98, 1.55)	0.078	1.17 (0.93, 1.49)	0.19
Cardiovascular Death
All	330	2.9 (2.6, 3.2)	1.33 (1.07, 1.66)	0.012	1.31 (1.04, 1.65)	0.021
Women	135	2.3 (1.9, 2.7)	1.51 (1.06, 2.15)	0.021	1.48 (1.03, 2.14)	0.035	0.34
Men	195	3.6 (3.1, 4.1)	1.22 (0.92, 1.62)	0.18	1.21 (0.90, 1.63)	0.21

^*Adjusted for age, race, and gender.

^†Adjusted for Model 1 covariates plus smoking, systolic blood pressure, diabetes, body mass index, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, beta blockers, statin, randomization group, New York Heart Association functional classification, coronary heart disease, and stroke.

CI=confidence interval; HR=hazard ratio.