Table 3.
Multivariable analysis* of vitamin D insufficiency and lung function measures, NHANES 2007–2010
| Lung Function Measures | Children (n=3,001) | Adults (n=8,347) |
|---|---|---|
|
| ||
| β (95% confidence interval), P-value | ||
| Pre-bronchodilator FEV1 (mL)1 | −110.17 (−146.79, −75.54), <0.01 | −69.68 (−94.17, −45.18), <0.01 |
| Pre-bronchodilator FVC, (mL)1 | −129.13 (−176.09, −82.19), <0.01 | −118.11 (−150.43, −85.79), <0.01 |
| Pre-bronchodilator FEV1/FVC (%) | −0.06 (−0.84, 0.72), 0.88 | 0.45 (0.05, 0.85), 0.03 |
| Bronchodilator response (BDR,%)2,3 | 0.50 (0.20, 1.21), 0.12 | 0.69 (0.36, 1.36), 0.29 |
*
All models were adjusted for age, gender, race/ethnicity, household income, current asthma, cotinine, C-reactive protein, BMI (in adults) or BMIZ (in children).
1
Additionally adjusted for height and height square
2
The model for bronchodilator response were additionally adjusting for baseline (pre-bronchodilator) FEV1.
3
Bronchodilator response defined as ≥ 12% increment from baseline FEV1 in children, and as ≥12% and ≥ 200ml increment from baseline in adults P for linear trend calculated using generalized linear models