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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Curr Opin Neurobiol. 2016 Nov 10;43:15–24. doi: 10.1016/j.conb.2016.10.002

Figure 3. MiR-980 impacts MB excitability to influence memory formation.

Figure 3

In adult flies, miR-980 controls A2bp1 expression in most of the neuronal populations involved in olfactory memory formation, including olfactory receptor neurons (ORn), projection neurons (Pn), and mushroom body neurons (MBn) (Figure 2A). MiR-980 inhibition releases A2bp1 repression producing an increase in neuronal excitability and calcium responses induced by odor presentation to the fly. The increase in A2bp1 expression leads to an increase in memory performance. MiR-980 over-expression or A2bp1 inhibition produces the opposite phenotype of memory impairment. This is associated with decreased neuronal excitability and calcium signaling.