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. Author manuscript; available in PMC: 2017 Jun 19.
Published in final edited form as: Mucosal Immunol. 2016 Nov 9;10(4):1008–1020. doi: 10.1038/mi.2016.100

Figure 1.

Figure 1

Varying perforin and GrzB expression between blood and rectal CD8+ T-cells and across HIV-infection. (a) Representative flow cytometry plot of intracellular perforin and GrzB expression in unstimulated ex vivo blood and rectal mucosal CD8+ T-cells from representative participants: viremic untreated (top) and seronegative (bottom). (b) Difference in intracellular perforin and GrzB expression between blood and rectal CD8+ T-cells in a consolidated group of all HIV+ participants compared to seronegative (SN) participants. (c) Difference in intracellular perforin and GrzB expression in rectal and blood CD8+ T-cells across HIV-disease status. (d) Spearman correlation analysis relating the frequency of GrzB+ CD8+ T-cells with the frequency of perforin+ CD8+ T-cells in rectal mucosa and blood. Wide horizontal bars represent medians; narrow whiskers indicate interquartile ranges; asterisks show level of significance as follows: * P <0.05, ** P <0.01, *** P <0.001, **** P <0.0001.