Table 2.

Materials, drug classes, and time points proposed for greatest treatment efficacy at each stage to achieve maximum functional recovery.

Stage	Material Type	Drug class	Administration window (hrs post-injury)
Acute	Hydrogel, Nanoparticles	Anti-inflammatory	0–2
Inflammatory	Hydrogel, Nanoparticles	Anti-inflammatory, Anti-apoptotic, Anti-oxidant	2–72
Proliferative	Conduits, Fibers	Anti-inhibition, Growth factors	48–336
Chronic	Conduits, Fibers	Growth factors	336+