Table 1.

Information of databases used in this study

Abbreviation	Full name	Purpose	Link
KEGG	Kyoto encyclopedia of genes and genomes	Obtain genome annotation, reaction information chemical compounds annotation	http://www.genome.jp/dbget-bin/www_bfind?compound
CheBI	Chemical entities of biological interest	Obtain chemical compounds annotation	https://www.ebi.ac.uk/chebi/
BiGG	Biochemical genetic and genomic knowledgebase	Obtain reaction information and chemical compounds annotation	http://bigg.ucsd.edu/bigg/main.pl
Ensembl fungi	Ensembl fungi	Obtain genome annotations	http://fungi.ensembl.org/index.html
UniProtKB	The universal protein resource knowledgebase	Obtain genome annotations	http://www.uniprot.org/
IMG	The integrated microbial genomes system	Obtain genome annotations	http://img.jgi.doe.gov/
ENZYME	Enzyme nomenclature database	Obtain relations between enzyme and reactions	http://enzyme.expasy.org/