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. 2016 Jul 19;42(3):461–469. doi: 10.1007/s13318-016-0359-9

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Arithmetic mean (± standard deviation [SD]) plasma concentration–time profiles for afatinib following a single 40 mg dose in subjects with moderate (n = 8) (a) and severe (n = 8) (b) renal impairment compared with matched healthy controls (linear scale). For clarity, data points have been shifted on the x-axis to avoid overlap of error bars and only one whisker of SD is shown per group (renal impairment +SD, healthy subjects −SD)