Table 1.

Baseline characteristics of the study population included in pharmacokinetic analysis

Characteristic	Normal renal function (n = 14)a	Moderate renal impairment (n = 8)	Severe renal impairment (n = 8)
Male [no. (%)]	7 (50.0)	3 (37.5)	6 (75.0)
Age (years)	62.1 ± 11.4	68.6 ± 11.0	61.0 ± 11.9
White race [no. (%)]	14 (100.0)	8 (100.0)	8 (100.0)
BMI (kg/m2)	26.0 ± 3.2	26.1 ± 4.6	27.6 ± 3.4
eGFR (mL/min/1.73 m2)	100.9 ± 10.9	44.1 ± 11.1	20.0 ± 3.9

All data are mean ± SD unless stated otherwise. eGFR calculated using the Modification of Diet in Renal Disease Formula [15]

BMI body mass index, eGFR estimated glomerular filtration rate, SD standard deviation

^aMatched to subjects with moderate and severe renal impairment. Two healthy subjects were matched both to subjects with severe impairment and to subjects with moderate impairment