Table 4.

Subgroup analysis between T risk allele with modifiable exposure and clinical phenotype.

Characteristic	Without the risk allele (N = 446)	With the risk allele (N = 53)	P-value
Sex (male/female)	284/162	37/16	0.449
Mean age at onset (SD) (year)	51.20 ± 11.99	52.02 ± 10.89	0.630
Site of onset (bulbar/spinal)	78/368	10/43	0.803
Disease progression: ΔFS Median (25th, 75th percentiles)	0.54 (0.29–0.88)	0.52 (0.22–0.88)	0.907
Smoking	111/335	14/39	0.808
Alcohol abusing	83/363	12/41	0.480
Pesticides exposure	68/378	8/45	0.977