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. 2017 May 10;8:263. doi: 10.3389/fphar.2017.00263

FIGURE 6.

FIGURE 6

Association of immune response with clinical outcome. (A) Survival of patients according to median (12,800) of anti-HER1-ECD antibody titers developed in all the evaluated patients. Patients were divided according to maximum titer reached during vaccination. Although non-significant, patients with antibody titers higher or equal than 12,800 seem to have better survival times as compared to patients with lower antibody response (median, 27.95 vs. 10.02, p = 0.081, log rank test). (B) Survival of patients according to IFN-γ-secreting T cells measured as SFU. Patients with at least medium number of spot (Dpost-D0 ≥ 50 spots) seem to have better survival in comparison with patients with either lower number of spot (Dpost-D0 < 50 spots) or negative T cell response (Dpost-D0 < 10 spots) (median, not reached vs. 14.85 months, p = 0.039, log rank test).