Fig. 2.

Predicted Css by age split by co-administration with PB, CBZ and VPA or absence of PB/CBZ/VPA using the final paediatric population PK model (red circles: individual predictions) for children from the NHANES database using 2 mg/kg bid for patients <8 years, and 1.6 mg/kg bid for patients ≥8 years with 100 mg bid maximum dose. The blue line is the median simulated paediatric Css and the blue shaded area encompasses 90% of the simulated paediatric patients. The horizontal grey band encompasses 90% of the simulated adult patients receiving 100 mg bid