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. 2017 Mar 14;8:14689. doi: 10.1038/ncomms14689

Figure 1. Lipogenic characteristics of human and mouse liver tumours.

Figure 1

(a) ACACA mRNA expression in human non-cancerous liver and HCC tumour tissue. (b) ACACA expression adjusted by HCC grade. For b, * indicates significant difference from Grade 1 HCC. (c) ACACB mRNA expression in human non-cancerous liver and HCC. (d) ACACB expression adjusted by HCC grade. (e) Acaca and (f) Acacb mRNA expression in liver non-tumour or tumour tissue of wild-type C57BL/6 mice untreated or treated with DEN at 2 weeks of age and collected at 32 weeks of age (n=4 untreated and 9 DEN-treated mice). (g) Rates of lipogenesis from glucose in non-cancerous cells (primary murine hepatocytes and human PH5CH8 cells), and liver cancer cells lines from human (HepG2 and HuH7) and murine (Hepa1-6 and Hepa-1c1c7) origin (n=at least three independent experiments). * Indicates significant difference, P<0.05 as determined by two-tailed t-test (b,d and e–g were analysed by one-way analysis of variance followed by Tukey's post hoc analysis.) Data are represented as mean±s.e.m.