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. 2017 Mar 14;8:14689. doi: 10.1038/ncomms14689

Figure 2. ACC deletion increases diethylnitrosamine-induced tumorigenesis in mice.

Figure 2

(a) Representative images of livers from LDKO and floxed littermate control (Flox) mice treated with DEN at 2 weeks of age and collected at 40 weeks of age. Scale bar, 1 cm. (b) Liver tumour incidence and (c) multiplicity of DEN-treated LDKO and Flox mice. (d) ACC protein expression and (e) rates of lipogenesis from acetate with or without the pan-ACC inhibitor K1 (10 μM) in cells derived from tumour tissue of DEN-treated wild-type and LDKO mice (n=3 independent experiments). * Indicates significant difference, P<0.05 as determined by two-tailed t-test. Data are represented as mean±s.e.m.