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. 2017 Mar 14;8:14689. doi: 10.1038/ncomms14689

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Copyright © 2017, The Author(s)

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Histological characterization of (a) portal and (b) lobular inflammation in livers of DEN-treated LDKO and Flox mice at 40 weeks of age. (c) Metabolomics-based pathway enrichment analysis of glutathione metabolism in DEN-treated livers from LDKO mice relative to Flox mice at 40 weeks of age. Red colour indicates a significant increase in metabolite levels, green indicates a significant decrease in metabolite levels and grey indicates no significant difference in LDKO/Flox levels. Circle size corresponds with the relative magnitude of difference between LDKO/Flox levels. Levels of (d) 6-phosphogluconate, (e) NADPH and (f) GSH:GSSG in liver tissue extracts of DEN-treated LDKO and Flox mice at 40 weeks of age. * Indicates significant difference, P<0.05 as determined by two-tailed t-test. For a,b and d–f, n=10 Flox and 11 LDKO mice. For c, n=6 mice. Data are represented as mean±s.e.m.