Figure 6. LDKO livers are resistant to DEN-induced DNA damage and apoptosis.

Representative images of immunohistochemical staining and quantification for (a,b) γH2A.X, (c,d) cleaved CASP3 and (e,f) Ki67 in liver sections of LDKO and Flox mice treated with vehicle (Mock) or DEN at 14 days of age and collected 24 h after treatment (scale bars, 50 μm; n=4 mice). * Indicates significant difference, P<0.05 as determined by one-way analysis of variance followed by Tukey's post hoc analyses. Data are represented as mean±s.e.m.