Table 3.

Associations of maternal polygenic risk scores (PGS) with childhood educational outcomes and childhood polygenic risk scores with maternal educational outcomes

Outcome	Predictor	N	Beta coefficient (95% CIs)	P-value	R2
Key Stage 3 points	Maternal PGS adjusted for childhood PGS	4239	−1.1 (−1.8 to −0.3)	0.007	0.02
Key Stage 3 points	Maternal PGS	4239	−1.4 (−2.1 to −0.9)	1.7 × 10−6	0.02
Capped GCSE points	Maternal PGS adjusted for childhood PGS	4263	−2.9 (−5.7 to −0.2)	0.036	0.03
Capped GCSE points	Maternal PGS	4263	−4.3 (−6.4 to −2.1)	9 × 10−5	0.03
Mother’s highest qualification	Childhood PGS	5004	−0.06 (−0.10 to −0.02)	0.002	0.008

CIs, Confidence Intervals; PGS, Polygenic Risk Score; GCSE, General Certificate of Secondary Education