Table 4. Gene expression level changes in GC with TNIK amplification.
| Gene | Name | Fold increase (AMP/non-AMP) | P-value |
|---|---|---|---|
| RSC1A1 | Regulatory solute carrier protein, family 1, member 1 | 215.84 | 0.032 |
| TAS2R30 | Taste receptor, type 2, member 30 | 75.51 | 0.022 |
| TAS2R31 | Taste receptor, type 2, member 31 | 75.09 | 0.032 |
| TAS2R46 | Taste receptor, type 2, member 46 | 61.29 | 0.026 |
| GPR22 | G protein-coupled receptor 22 | 58.39 | 0.021 |
| TAS2R50 | Taste receptor, type 2, member 50 | 54.42 | 0.029 |
| KCTD4 | Potassium channel tetramerization domain containing 4 | 42.92 | 0.019 |
| GPR52 | G protein-coupled receptor 52 | 39.14 | 0.034 |
| AQP4 | aquaporin 4 | 37.99 | 0.001 |
| HIST1H1A | Histone cluster 1, H1a | 32.43 | 0.037 |
| TAS2R19 | Taste receptor, type 2, member 19 | 32.01 | 0.033 |
| KCNIP4 | Kv channel interacting protein 4 | 31.71 | 0.043 |
| TMEM14E | Transmembrane protein 14E | 26.16 | 0.016 |
| HIST1H1T | Histone cluster 1, H1t | 23.23 | 0.022 |
| RANBP17 | RAN binding protein 17 | 22.73 | 0.025 |
| MAB21L2 | Mab-21-like 2 (C. elegans) | 20.49 | 0.037 |
| PSG2 | Pregnancy specific beta-1-glycoprotein 2 | 19.76 | 0.049 |
| OR2B2 | Olfactory receptor, family 2, subfamily B, member 2 | 19.52 | 0.010 |
| ADAM20 | ADAM metallopeptidase domain 20 | 18.71 | 0.047 |
| SCN9A | Sodium channel, voltage-gated, type IX, alpha subunit | 18.36 | 0.014 |
| IFNK | Interferon, kappa | 18.19 | 0.037 |
| B3GALT2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 | 16.65 | 0.046 |
| TAS2R20 | Taste receptor, type 2, member 20 | 16.45 | 0.028 |
| LRRK2 | Leucine-rich repeat kinase 2 | 16.29 | 0.037 |
| ZNF724P | Zinc finger protein 724, pseudogene | 16.23 | 0.038 |
| ZBTB41 | Zinc finger and BTB domain containing 41 | 15.94 | 0.033 |
| ZNF460 | Zinc finger protein 460 | 15.69 | 0.018 |
| GCNT7 | Glucosaminyl (N-acetyl) transferase family member 7 | 14.61 | 0.032 |
| RNF148 | Ring finger protein 148 | 14.60 | 0.047 |
| MEGF11 | Multiple EGF-like-domains 11 | 13.79 | 0.037 |
| GLIPR1L1 | GLI pathogenesis-related 1 like 1 | 12.45 | 0.046 |
| ESRRG | Estrogen-related receptor gamma | 12.38 | 0.007 |
| TMEM170B | Transmembrane protein 170B | 12.13 | 0.014 |
| ZBED6 | Zinc finger, BED-type containing 6 | 12.13 | 0.015 |
| LRRN3 | Leucine-rich repeat neuronal 3 | 11.71 | 0.028 |
| SLC5A3 | Solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 11.71 | 0.033 |
| PIK3CA | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 11.43 | 0.021 |
| SACS | Spastic ataxia of Charlevoix-Saguenay (sacsin) | 11.19 | 0.041 |
| MCTP1 | Multiple C2 domains, transmembrane 1 | 11.12 | 0.038 |
| SESN3 | Sestrin 3 | 11.07 | 0.020 |
| PP2D1 | Protein phosphatase 2C-like domain containing 1 | 11.04 | 0.020 |
| UTY | Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 11.03 | 0.017 |
| TET1 | Tet methylcytosine dioxygenase 1 | 10.93 | 0.045 |
| TRPS1 | Trichorhinophalangeal syndrome I | 10.75 | 0.021 |
| ST7-OT4 | ST7 overlapping transcript 4 | 10.63 | 0.023 |
| GDF5OS | Growth differentiation factor 5 opposite strand | 10.38 | 0.046 |
| COMP | Cartilage oligomeric matrix protein | 0.10 | 0.005 |
| DERL3 | Derlin 3 | 0.07 | 0.024 |
Abbreviation: TNIK, Traf2- and Nck-interacting kinase.