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Nimbolide alters MOMP in WM cells. (a and b) WM cell lines were treated with nimbolide at different concentrations for 6 h and subsequently incubated with 20 nM TMRM for 15 min followed by flow cytometry for analysis of MOMP. MOMP was most activated at 1 μM, particularly bortezomib-resistant (BC/BR) WM cells (69% MOMP). All experiments were performed in triplicate. **P<0.01. WM tumor cell lines: BC, BCWM.1; BC/IR, BCWM.1/IR; BC/BR, BCWM.1/BR; MW, MWCL-1; RP, RPCI-WM1.
