Figure 3.

Homer 1a regulates group I mGluRs in traumatic injury. Mice cortical neuronal cultures were transfected with different lentiviruses. After transfection, the neuronal cultures were pretreated with (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) (100 μM) (a–c), (2S)-2-amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid (LY341495) (100 μM) (d–f), or (RS)-α-methylserine-O-phosphate (MSOP) (100 μM) (g–i). Cell viability, cytotoxicity, and cell death rate were measured in neuronal cultures after traumatic injury. The data are represented as the mean±S.E.M. from five experiments. The data are represented as the mean±S.E.M. from five experiments. *P<0.05 versus vector; ^#P<0.05 versus short hairpin RNA (shRNA) Con. Mice cortical neuronal cultures were transfected with different lentiviruses. After transfection, the neuronal cultures were treated with DHPG (100 μM). Cell viability, cytotoxicity, and cell death rate were measured (j–l). The data are represented as the mean±S.E.M. from five experiments. *P<0.05 versus vector; ^#P<0.05 versus shRNA Con