Table 1. IC50 values for MPT0G009 or SAHA for different recombinant HDAC isoforms.
IC50
(nM) of HDAC isoforms enzymea |
||||||
---|---|---|---|---|---|---|
Compound | HDAC1 | HDAC2 | HDAC3 | DHAC8 | HDAC4 | HDAC6 |
MPT0G009 | 4.62±0.81 | 5.16±0.76 | 1.91±0.22 | 22.48±2.16 | >104 | 8.43±0.72 |
SAHA | 45.97±5.62 | 96.90±8.43 | 33.87±2.38 | 542.83±32.73 | >104 | 15.50±1.38 |
Data represent the mean±S.E.M. from three replicate experiments