Table 1.
Main characteristics and results of the studies in meta-analysis published in the period from 2012 to 2016 and included in systematic search.
| Med | Author and reference | Year | N | Polymorphisms | Cases/controls | OR (IC 95%, Pvalue) | Periodontitis classification |
|---|---|---|---|---|---|---|---|
| IL-1A | Wang et al. [18] | 2014 | 19 | −889 C/T | 1,266/2,134 | 1.00 (0.88–1.14, P = 0.98) | Aggressive |
| Silva et al. [15] | 2017 | 23 | −889 C/T | 2,174/1,756 | 1.22 (1.09–1.36, P < 0.0004) | Chronic | |
|
| |||||||
| IL-1B | Zeng et al. [19] | 2015 | 19 | −511 C/T | 2,173/3,900 | 1.03 (0.72–1.46, P = 0.88) | Chronic |
| Chen et al. [20] | 2015 | 25 | +3954 C/T | 1,594/2,483 | 0.99 (0.79–1.23, P = 0.91) | Aggressive | |
| Ma et al. [21] | 2015 | 20 | +3954 C/T | 1,656/1,498 | 1.60 (1.06–2.42, P = 0.02) | Chronic | |
|
| |||||||
| IL-4 | Yan et al. [17] | 2015 | 12 7 4 |
−590 C/T −33 C/T 70 pb |
1,220/2,039 715/967 426/506 |
1.20 (0.78–1.85, P = 0.42) 0.97 (0.60–1.58, P = 0.91) 1.26 (0.76–2.11, P = 0.37) |
Aggressive Chronic |
|
| |||||||
| IL-6 | Song et al. [22] | 2013 | 16 10 |
−174 G/C −572 G/C |
1,887/1,490 1,436/998 |
1.18 (0.91–1.55, P = 0.20) 1.52 (1.15–2.00, P = 0.003) |
Aggressive Chronic |
|
| |||||||
| IL-8 | Chen et al. [23] | 2015 | 11 3 |
−251 A/T −845 T/C |
1,555/2,130 678/525 |
0.89 (0.70–1.12, P < 0.001) 1.41 (0.99–2.01, P = 0.40) |
Aggressive Chronic |
|
| |||||||
| IL-10 | Zhong et al. [24] | 2012 | 5 7 6 |
−1082 A/G −819 C/T −592 C/A |
1,105/976 749/603 673/587 |
0.96 (0.73–1.26, P = 0.77) 1.13 (0.96–1.33, P = 0.16) 1.38 (1.04–1.85, P = 0.03) |
Aggressive Chronic |
|
| |||||||
| IL-18 | Li et al. [25] | 2014 | 3 3 |
−607 A/C −137 G/C |
576/458 576/458 |
1.86 (1.30–2.65, P = 0.192) 1.66 (1.37–2.02, P = 0.281) |
Aggressive Chronic |
|
| |||||||
| FCGR2A FCGR3A FCGR3B |
Song and Lee [10] | 2013 | 7 6 1 3 3 3 |
R131H F158V NA1/NA2 |
1,626/1,496 7,68/1,256 178/128 434 512668/490 320/364 |
0.947 (0.814–1.103, P = 0.485) 1.112 (0.918–1.348, P = 0.278) 1.371 (0.810–2.320, P = 0.240) 0.940 (0.673–1.315, P = 0.719) 1.026 (0.806–1.305, P = 0.836) 2.138 (0.956–4.784, P = 0.064) |
Chronic Aggressive Chronic Aggressive Chronic Aggressive |
|
| |||||||
| COX-2 | Jiang et al. [8] | 2014 | 5 2 3 1 2 |
−765G/C −1195G/A 8473 T/C |
1,913/2,984 604/1192 1,231/2,138 519/1036 202/208 |
1.11 (0.79–1.55, P > 0.005) 1.15 (0.81–1.64, P > 0.005) 0.40 (0.03–5.44, P > 0.005) 1.25 (0.87–1.80, P > 0.005) 0.65 (0.46–0.91, P > 0.005) |
Chronic Aggressive Chronic Aggressive Chronic |
|
| |||||||
| MMP-2 MMP-3 MMP-8 MMP-9 |
Weng et al. [11] | 2016 | 2 2 6 1 2 2 7 2 |
−753 C/T −1171 A5/A6 −799C/T −1562 C/T |
236/234 171/280 697/1,530 37/142 702/384 1,96/167 859/1,186 191/285 |
1.28 (1.07–1.54 P > 0.005) 2.01 (0.98–4.11, P > 0.005) 1.44 (1.25–1.66, P < 0.001) 1.54 (0.82–2.89, P = 0.175) 1.28 (1.07–1.54, P > 0.005) 2.01 (0.98–4.11, P > 0.005) 0.49 (0.31–0.77, P = 0.002) 0.93 (0.67–1.29, P = 0.656) |
Chronic Aggressive Chronic Aggressive Chronic Aggressive Chronic Aggressive |
Med: inflammatory mediator, IL: interleukins, FGCGR: receptor Fcγ, COX-2: cyclooxygenase 2, MMP: matrix metalloproteinase, N: number of studies included in meta-analysis available, OR: Odds Ratio for the allelic evaluation (mutants allelic × wild allelic comparison), IC: confidence interval, pb: bases pair, and P < 0.05: statistic value significant.