Table 2.
Statistical characteristics and results about heterogeneity value of the studies in meta-analysis and included in systematic search.
| Med | Author and reference | Polymorphism | I 2 (%) | P heterogeneity | Statistical model used | Periodontitis classification |
|---|---|---|---|---|---|---|
| IL-1A | Wang et al. [18] | −889 C/T | 28.86 | P > 0.05 | FE | Aggressive |
| Silva et al. [15] | −889 C/T | 15 | P = 0.28 | FE | Chronic | |
|
| ||||||
| IL-1B | Zeng et al. [19] | −511 C/T | 79.54 | P < 0.05 | RE | Chronic |
| Chen et al. [20] | +3954 C/T | 62.2 | P < 0.05 | RE | Aggressive | |
| Ma et al. [21] | +3954 C/T | 81% | P < 0.05 | RE | Chronic | |
|
| ||||||
| IL-4 | Yan et al. [17] | −590 C/T −33 C/T 70 pb |
90.4 85.7 75.1 |
P < 0.05 P < 0.05 P < 0.05 |
RE RE RE |
Aggressive/chronic |
|
| ||||||
| IL-6 | Song et al. [22] | −174 G/C −572 G/C |
64.9 61.8 |
P < 0.05 P < 0.05 |
RE RE |
Aggressive/chronic |
|
| ||||||
| IL-8 | Chen et al. [23] | −251 A/T −845 T/C |
NR NR |
P < 0.001 P = 0.40 |
RE FE |
Aggressive/chronic |
|
| ||||||
| IL-10 | Zhong et al. [24] | −1082 A/G −819 C/T −592 C/A |
23.9 29.8 56.6 |
P = 0.26 P = 0.20 P = 0.04 |
FE FE RE |
Aggressive/chronic |
|
| ||||||
| IL-18 | Li et al. [25] | −607 A/C −137 G/C |
38.1 0 |
P = 0.19 P = 0.97 |
FE FE |
Aggressive/chronic |
|
| ||||||
| FCGR2A FCGR3A FCGR3B |
Song and Lee [10] | R131H F158V NA1/NA2 |
5.95 0 NA 0 0 84.7 |
P = 0.45 P = 0.49 NA P = 0.48 P = 0.56 P = 0.001 |
FE FE NA FE FE RE |
Chronic Aggressive Chronic Aggressive Chronic Aggressive |
|
| ||||||
| COX-2 | Jiang et al. [8] | −765G/C −1195G/A 8473 T/C |
95.4 96.7 75.9 NA 0 |
P < 0.05 P < 0.05 P < 0.05 NA P > 0.05 |
RE RE RE NA FE |
Chronic Aggressive Chronic Aggressive Chronic |
|
| ||||||
| MMP-2 MMP-3 MMP-8 MMP-9 |
Weng et al. [11] | −753 C/T −1171 A5/A6 −799C/T −1562 C/T |
0 29.9 34.4 NA 0 85.3 85.8 0 |
P > 0.05 P > 0.05 P = 0.17 NA P > 0.05 P < 0.05 P < 0.001 P = 0.49 |
FE FE FE NA FE RE RE FE |
Chronic Aggressive Chronic Aggressive Chronic Aggressive Chronic Aggressive |
Med: inflammatory mediator, IL: interleukins, FGCGR: receptor Fcγ, COX-2: cyclooxygenase 2, MMP: matrix metalloproteinase, I2: chi-squared based Q statistic test, NR: not reported, NA: not applicable, and P < 0.05: statistic value significant.