Table 3.
Effects of MTPE on markers of toxicity and antioxidant activity after 21 days of treatment.
| Groups | Parameters | ||||||
|---|---|---|---|---|---|---|---|
| ALT (UI/L) |
AST (UI/L) |
Creatinine (mg/L) |
MDA (μM) |
Glutathione (μM) | TAOS (μM) | Total protein (g/L) |
|
| Untreated control | 64.20 ± 2.48 | 78.80 ± 6.37 | 22.0 ± 0.44 | 1.60 ± 0.25 | 9.28 ± 1.96 | 23.00 ± 0.02 | 97.80 ± 4.32 |
| Diabetic control | 156.20 ± 2.68∗ | 205.20 ± 0.44∗ | 130.0 ± 0.70∗ | 4.48 ± 0.63∗ | 5.10 ± 0.70∗ | 7.00 ± 0.04∗ | 40.80 ± 2.16∗ |
| Diabetic + glibenclamide 6.5 mg/kg | 68.20 ± 3.19b | 87.40 ± 4.33b | 44.0 ± 0.54b | 2.94 ± 0.28a | 14.22 ± 3.47a | 3.90 ± 0.03a | 80.20 ± 2.16a |
| Diabetic + MTPE 50 mg/kg | 117.00 ± 8.94b | 84.00 ± 5.78b | 68.0 ± 0.44b | 3.46 ± 0.42a | 9.06 ± 1.03a | 16.00 ± 0.03a | 75.60 ± 4.27a |
| Diabetic + MTPE 100 mg/kg | 95.00 ± 2.82b | 84.80 ± 2.94b | 50.0 ± 1.22b | 2.34 ± 0.41a | 13.90 ± 2.35a | 23.00 ± 0.02a | 81.00 ± 4.24a |
| Diabetic + MTPE 200 mg/kg | 60.00 ± 4.18b | 59.20 ± 3.03b | 38.0 ± 0.44b | 1.72 ± 0.17a | 15.50 ± 2.41a | 26.00 ± 0.01a | 90.40 ± 3.28a |
Values are expressed as means ± standard error (n = 5).
Values affected with the letters a and b are significantly different (p < 0.005) from the diabetic control.
Values affected with ∗ are significantly different (p < 0.001) from the normal control.