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. 2017 May 8;8:15111. doi: 10.1038/ncomms15111

Figure 10. TAp63α is up-regulated in the liver of obese patients with NAFLD/NASH.

Figure 10

Correlations between (a) BMI and TAp63α; (b) BMI and NAS score; (c) TAp63α and NAS score; (d) Liver mRNA levels of TAp63, IKKβ and XBP1s in subjects without NAFLD (n=18) and with NAFLD (n=48). HRPT was used to normalize mRNA levels; and (e) Representative photomicrographs of an immunohistochemistry against TAp63 in human liver slices from lean (n=11), NAFLD (n=23) and NASH (n=19) patients. (f) Schematic representation of the pathway proposed to modulate lipid metabolism in liver. Data are presented as mean±standard error mean (s.e.m.). Statistical differences are denoted by *P<0.05, **P<0.01 and ***P<0.001, was tested using Student t-test.