Table 2.
Femoral microarchitecture assessed by μCT of 1 and 3 month old HeyL null male mice and littermate controls.
| 1 Month | 3 Months | |||
|---|---|---|---|---|
| Control | HeyL null | Control | HeyL null | |
| Distal Femur Trabecular Bone | ||||
| Bone Volume/Total Volume (%) | 6.6 ± 0.7 | 5.1 ± 0.3* | 8.4 ± 1.6 | 8.0 ± 0.5 |
| Trabecular Separation (μm) | 213 ± 8 | 208 ± 6 | 203 ± 10 | 197 ± 5 |
| Trabecular Number (1/mm) | 4.8 ± 0.2 | 4.9 ± 0.1 | 4.9 ± 0.2 | 5.0 ± 0.1 |
| Trabecular Thickness (μm) | 24 ± 1 | 22 ± 1* | 33 ± 2 | 31 ± 1 |
| Connectivity Density (1/mm3) | 379 ± 51 | 288 ± 34 | 240 ± 42 | 260 ± 20 |
| Structure Model Index | 2.5 ± 0.1 | 2.8 ± 0.1* | 2.3 ± 0.2 | 2.4 ± 0.1 |
| Density of Material (mg HA/cm3) | 853 ± 4 | 891 ± 8* | 966 ± 9 | 963 ± 5 |
| Femoral Midshaft Cortical Bone | ||||
| Bone Volume/Total Volume (%) | 89.2 ± 0.3 | 89.3 ± 0.4 | 88.6 ± 0.2 | 89.0 ± 0.3 |
| Porosity (%) | 10.8 ± 0.3 | 10.7 ± 0.4 | 11.4 ± 0.2 | 11.0 ± 0.3 |
| Cortical Thickness (μm) | 93 ± 1 | 94 ± 2 | 150 ± 4 | 152 ± 4 |
| Total Area (mm2) | 1.46 ± 0.08 | 1.53 ± 0.05 | 1.59 ± 0.08 | 1.58 ± 0.05 |
| Bone Area (mm2) | 0.45 ± 0.03 | 0.45 ± 0.02 | 0.73 ± 0.04 | 0.72 ± 0.02 |
| Periosteal Perimeter (mm) | 4.3 ± 0.1 | 4.4 ± 0.1 | 4.5 ± 0.1 | 4.4 ± 0.1 |
| Endocortical Perimeter (mm) | 3.6 ± 0.1 | 3.7 ± 0.1 | 3.3 ± 0.1 | 3.3 ± 0.1 |
| Density of Material (mg HA/cm3) | 935 ± 5 | 937 ± 7 | 1159 ± 4 | 1165 ± 8 |
μCT was performed on distal femurs for trabecular bone and midshaft for cortical bone from 1 and 3 month old male HeyL null mice and control male littermates (Control). Values are means ± SEM; n = 4 to 9.
*
Significantly different between HeyL null and control, p < 0.05.