Table 3.
Femoral microarchitecture assessed by μCT of 1 and 3 month old HeyL null female mice and littermate controls.
| 1 Month | 3 Months | |||
|---|---|---|---|---|
| Control | HeyL null | Control | HeyL null | |
| Distal Femur Trabecular Bone | ||||
| Bone Volume/Total Volume (%) | 3.6 ± 0.4 | 3.6 ± 0.4 | 4.5 ± 0.5 | 4.7 ± 0.7 |
| Trabecular Separation (μm) | 265 ± 16 | 247 ± 14 | 278 ± 11 | 301 ± 10 |
| Trabecular Number (1/mm) | 3.9 ± 0.3 | 4.1 ± 0.2 | 3.6 ± 0.1 | 3.4 ± 0.1 |
| Trabecular Thickness (μm) | 22 ± 1 | 21 ± 1 | 34 ± 0 | 38 ± 2 |
| Connectivity Density (1/mm3) | 148 ± 3 | 98 ± 30 | 98 ± 16 | 89 ± 21 |
| Structure Model Index | 2.9 ± 0.1 | 3.0 ± 0.1 | 3.0 ± 0.1 | 2.9 ± 0.1 |
| Density of Material (mg HA/cm3) | 868 ± 8 | 894 ± 10 | 979 ± 8 | 995 ± 6 |
| Femoral Midshaft Cortical Bone | ||||
| Bone Volume/Total Volume (%) | 88.7 ± 0.2 | 89.0 ± 0.6 | 88.9 ± 0.2 | 88.4 ± 0.3 |
| Porosity (%) | 11.3 ± 0.2 | 11.0 ± 0.6 | 11.1 ± 0.2 | 11.6 ± 0.3 |
| Cortical Thickness (μm) | 90 ± 2 | 93 ± 2 | 156 ± 2 | 151 ± 3 |
| Total Area (mm2) | 1.42 ± 0.10 | 1.47 ± 0.08 | 1.54 ± 0.04 | 1.57 ± 0.03 |
| Bone Area (mm2) | 0.42 ± 0.02 | 0.43 ± 0.02 | 0.73 ± 0.02 | 0.74 ± 0.01 |
| Periosteal Perimeter (mm) | 4.2 ± 0.1 | 4.3 ± 0.1 | 4.4 ± 0.1 | 4.4 ± 0.1 |
| Endocortical Perimeter (mm) | 3.5 ± 0.1 | 3.6 ± 0.1 | 3.1 ± 0.1 | 3.2 ± 0.1 |
| Density of Material (mg HA/cm3) | 921 ±7 | 919 ± 10 | 1188 ± 3 | 1178 ± 7 |
μCT was performed on distal femurs for trabecular bone and midshaft for cortical bone from 1 and 3 month old female HeyL null mice and control female littermates (Control). Values are means ± SEM; n = 4 to 6.