Table 4.
Cancellous bone histomorphometry of 1 and 3 month old HeyL null male mice and littermate controls.
| 1 Month | 3 Months | |||
|---|---|---|---|---|
| Control | HeyL null | Control | HeyL null | |
| Distal Femur Trabecular Bone | ||||
| Bone Volume/Tissue Volume (%) | 7.6 ± 1.6 | 9.6 ± 1.1 | 11.3 ± 2.2 | 9.4 ± 0.2 |
| Trabecular Number (1/mm) | 2.5 ± 0.3 | 3.4 ± 0.2* | 2.9 ± 0.2 | 3.1 ± 0.5 |
| Trabecular Thickness (μm) | 30 ± 3 | 28 ± 2 | 38 ± 5 | 31 ± 1 |
| Osteoblasts/Bone Perimeter (1/mm) | 19.9 ± 3.6 | 20.1 ± 2.3 | 10.1 ± 1.6 | 10.2 ± 1.7 |
| Osteoid Surface/Bone Surface (%) | 1.4 ± 0.2 | 1.2 ± 0.4 | 2.7 ± 0.9 | 1.2 ± 0.2 |
| Osteoclasts/Bone Perimeter (1/mm) | 6.8 ± 0.6 | 6.6 ± 0.5 | 4.9 ± 0.3 | 5.6 ± 0.5 |
| Eroded Surface/Bone Surface (%) | 16.6 ± 1.6 | 17.4 ± 1.2 | 8.9 ± 0.7 | 9.3 ± 0.7 |
| Mineral Apposition Rate (μm/day) | 3.3 ± 0.1 | 3.7 ± 0.4 | 0.9 ± 0.1 | 1.1 ± 0.1 |
| Mineralizing Surface/Bone Surface (%) | 7.8 ± 2.0 | 4.1 ± 0.3 | 3.1 ± 0.6 | 3.0 ± 1.0 |
| Bone Formation Rate (μm3/μm2/day) | 0.26 ± 0.08 | 0.15 ± 0.01 | 0.03 ± 0.01 | 0.03 ± 0.01 |
Bone histomorphometry was performed on distal femurs from 1 and 3 month old male HeyL null mice and control male littermates (Control). Values are means ± SEM; n = 3 to 6.
*
Significantly different between HeyL null and control, p < 0.05.