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In vitro drug susceptibility profiles of the FCB-KDmdr1 and FCB lines. Shown are the mean ± SEM IC50s of the pfmdr1 knockdown FCB-KDmdr1 and its parental FCB line to piperaquine (PPQ [left panel]), lumefantrine (LMF [middle panel]), and mefloquine (MFQ [right panel]). IC50s were determined in 72-h assays as per Fig. 3. Statistical comparisons of the FCB-KDmdr1 line to its nonrecombinant parental FCB line were made using two-tailed Mann-Whitney U tests. *, P < 0.05.
