Table 5.
Multivariate analyses of EORTC-QLQ-BR23
| Symptomatic subscale | ||||
| Side effects of systemic therapy OR (SE), p value |
Arm symptoms OR (SE), p value |
Breast symptoms OR (SE), p value |
Hair loss OR (SE), p value |
|
| Disease free period | ||||
| (3rd year/1st year) | 8.56 (1.69), <0.001 | 6.80 (1.32), <0.001 | ||
| (2nd year/1st year) | 5.82 (1.45), <0.001 | 4.66 (1.16), <0.001 | ||
| Disease stage | ||||
| (III-IV/0) | -4.70 (2.29), 0.041 | −4.21 (1.80), 0.019 | ||
| Axillary dissection | ||||
| (axillary/none) | −3.47 (0.98), <0.001 | −4.83 (1.50), 0.001 | −2.95 (1.17), 0.12 | −8.72 (2.70), 0.001 |
| Hormone therapy | ||||
| (yes/no) | −1.78 (0.56) 0.001 | |||
| Employment change | ||||
| (employed/employed➔unemployed) | 2.76 (1.34), | |||
| (unemployed/employed➔unemployed) | 0.039 | 2.48 (1.24), 0.046 | ||
| Educational status | ||||
| (high/low or middle) | 3.54 (1.43), 0.013 | |||
| Household income | ||||
| (low/high) | −4.23 (0.97), <0.001 | −3.33 (1.40), 0.018 | −2.12 (1.02), 0.038 | |
| Hobbies | ||||
| (active/rare) | 4.98 (1.14), <0.001 | 6.69 (1.58), <0.001 | 2.63 (1.24), 0.033 | 8.85 (3.34), 0.009 |
| Medication of psychotropic drug | - | |||
| (yes/no) | 9.90 (1.85), <0.001 | −7.09 (2.49), 0.004 | ||
| Medication of diabetes | ||||
| (yes/no) | −5.61 (2.52), 0.026 | |||
| Current smoking | ||||
| (yes/no) | −7.06 (2.99), 0.018 | |||
| Supplementary drug | ||||
| (yes/no) | −3.17 (0.95), 0.001 | |||
| Functional subscale | ||||
| Body Image OR (SE), p value |
Future perspective OR (SE), p value |
Sexual activity OR (SE), p value |
Sexual Enjoyment OR (SE), p value |
|
| Disease free period | ||||
| (3rd year/1st year) | 3.92 (1.83), 0.032 | |||
| Breast surgery | ||||
| (MRM/BCS) | -9.16 (2.82), 0.001 | |||
| Axillary dissection | ||||
| (axillary/none) | −5.55 (2.56), 0.031 | |||
| Chemotherapy | ||||
| (yes/no) | −3.40 (0.78), <0.001 | −1.15 (0.48), 0.018 | ||
| Hormone therapy | ||||
| (yes/no) | 2.80 (1.32), 0.034 | |||
| Radiotherapy field | ||||
| (breast/including regional nodes) | 11.22 (2.98), <0.001 | |||
| Menopausal status | ||||
| (post−/pre-) | 4.88 (1.55), 0.002 | 6.65 (2.00), 0.001 | ||
| Age group | ||||
| (>60/<40) | −9.78 (1.49), <0.001 | −38.16 (4.91), 0.001 | ||
| (51–60/<40) | −4.22 (1.00), <0.001 | −22.82 (4.11), <0.001 | ||
| (41–50/<40) | −13.26 (4.01), 0.001 | |||
| Employment change | ||||
| (employed/employed➔unemployed) | −8.74 (1.83), <0.001 | −8.63 (2.31), <0.001 | ||
| Household income | ||||
| (low/high) | −3.61 (1.54), 0.019 | −6.23 (1.98), 0.002 | ||
| Hobbies | ||||
| (active/rare) | 6.16 (1.81), 0.001 | 9.38 (2.31), <0.001 | 6.27 (1.41), <0.001 | 6.67 (2.53), 0.009 |
| (moderate/rare) | 5.08 (1.16), <0.001 | |||
| Medication of psychotropic drug | ||||
| (yes/no) | −11.59 (2.85), <0.001 | |||
| Alcohol consumption | ||||
| (yes/no) | −3.82 (1.77), 0.031 | |||
| Supplementary drug | ||||
| (yes/no) | −4.34 (1.50), 0.004 | −4.68 (1.95), 0.017 | ||
Negative sign is a negative effect and positive sign is a positive effect
Abbreviations: EORTC-QLQ-BR23, the EORTC Quality of Life Questionnaire–breast cancer specific module, OR odds ratio, SE standard error, MRM modified radical mastectomy, BCS breast conserving surgery